The role of P2X7 ATP receptors in the nervous system: potential implications in inflammatory and depression-like diseases
نویسندگان
چکیده
Background The P2X7 receptor is a ligand-gated ion channel expressed in neuronal, glial and immune cells and is implicated in a wide range of pathological conditions, including ischemia, and inflammation. The P2X7 receptor can modulate the maturation and release of the proinflammatory cytokine, interleukin-1β (IL-1β). IL-1β is suggested to be involved in the pathophysiology of depression and sickness behaviour, elicited by peripherally administered bacterial lipopolysaccharide (LPS).
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